Triptolide Induces Growth Inhibition and Apoptosis of Human Laryngocarcinoma Cells by Enhancing p53 Activities and Suppressing E6-Mediated p53 Degradation

Fei Zhao; Weiwei Huang; Tamgue Ousman; Bin Zhang; Yangyang Han; Daguia Zambe John Clotaire; Chen Wang; Huanhuan Chang; Huanan Luo; Xiaoyong Ren; Ming Lei

doi:10.1371/journal.pone.0080784

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Open Access

Peer-reviewed

Research Article

Triptolide Induces Growth Inhibition and Apoptosis of Human Laryngocarcinoma Cells by Enhancing p53 Activities and Suppressing E6-Mediated p53 Degradation

Fei Zhao ,

Contributed equally to this work with: Fei Zhao, Weiwei Huang

Affiliation Key Laboratory of Agricultural Molecular Biology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi Province, People's Republic of China
⨯
Weiwei Huang ,

Contributed equally to this work with: Fei Zhao, Weiwei Huang

Affiliation Key Laboratory of Agricultural Molecular Biology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi Province, People's Republic of China
⨯
Tamgue Ousman,

Affiliation Key Laboratory of Agricultural Molecular Biology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi Province, People's Republic of China
⨯
Bin Zhang,

Affiliation Key Laboratory of Agricultural Molecular Biology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi Province, People's Republic of China
⨯
Yangyang Han,

Affiliation Key Laboratory of Agricultural Molecular Biology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi Province, People's Republic of China
⨯
Daguia Zambe John Clotaire,

Affiliation Key Laboratory of Agricultural Molecular Biology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi Province, People's Republic of China
⨯
Chen Wang,

Affiliation Key Laboratory of Agricultural Molecular Biology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi Province, People's Republic of China
⨯
Huanhuan Chang,

Affiliation Department of Otolaryngology-Head and Neck Surgery, the Second Hospital, Xi’an Jiao Tong University, Xi’an, Shaanxi Province, People's Republic of China
⨯
Huanan Luo,

Affiliation Department of Otolaryngology-Head and Neck Surgery, the Second Hospital, Xi’an Jiao Tong University, Xi’an, Shaanxi Province, People's Republic of China
⨯
Xiaoyong Ren ,

* E-mail: leiming70@hotmail.com (ML); renxiaoyong@vip.sina.com (XR)

Affiliation Department of Otolaryngology-Head and Neck Surgery, the Second Hospital, Xi’an Jiao Tong University, Xi’an, Shaanxi Province, People's Republic of China
⨯
Ming Lei

* E-mail: leiming70@hotmail.com (ML); renxiaoyong@vip.sina.com (XR)

Affiliation Key Laboratory of Agricultural Molecular Biology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi Province, People's Republic of China
⨯

Triptolide Induces Growth Inhibition and Apoptosis of Human Laryngocarcinoma Cells by Enhancing p53 Activities and Suppressing E6-Mediated p53 Degradation

Fei Zhao,
Weiwei Huang,
Tamgue Ousman,
Bin Zhang,
Yangyang Han,
Daguia Zambe John Clotaire,
Chen Wang,
Huanhuan Chang,
Huanan Luo,
Xiaoyong Ren

Published: November 14, 2013
https://doi.org/10.1371/journal.pone.0080784

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