Fhit Deficiency-Induced Global Genome Instability Promotes Mutation and Clonal Expansion

Satoshi Miuma; Joshua C. Saldivar; Jenna R. Karras; Catherine E. Waters; Carolyn A. Paisie; Yao Wang; Victor Jin; Jin Sun; Teresa Druck; Jie Zhang; Kay Huebner

doi:10.1371/journal.pone.0080730

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Peer-reviewed

Research Article

Fhit Deficiency-Induced Global Genome Instability Promotes Mutation and Clonal Expansion

Satoshi Miuma,

Current address: Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Joshua C. Saldivar,

Current Address: Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Jenna R. Karras,

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Catherine E. Waters,

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Carolyn A. Paisie,

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Yao Wang,

Affiliation Department of Biomedical Informatics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Victor Jin,

Affiliation Department of Biomedical Informatics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Jin Sun,

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Teresa Druck,

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Jie Zhang,

Affiliation Department of Biomedical Informatics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯
Kay Huebner

* E-mail: kay.huebner@osumc.edu

Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America
⨯

Fhit Deficiency-Induced Global Genome Instability Promotes Mutation and Clonal Expansion

Satoshi Miuma,
Joshua C. Saldivar,
Jenna R. Karras,
Catherine E. Waters,
Carolyn A. Paisie,
Yao Wang,
Victor Jin,
Jin Sun,
Teresa Druck,
Jie Zhang

Published: November 14, 2013
https://doi.org/10.1371/journal.pone.0080730

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