Sustained Activation of Protein Kinase C Induces Delayed Phosphorylation and Regulates the Fate of Epidermal Growth Factor Receptor

Mengling Liu; Jolanta Idkowiak-Baldys; Patrick L. Roddy; Aleksander Baldys; John Raymond; Christopher J. Clarke; Yusuf A. Hannun

doi:10.1371/journal.pone.0080721

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Research Article

Sustained Activation of Protein Kinase C Induces Delayed Phosphorylation and Regulates the Fate of Epidermal Growth Factor Receptor

Mengling Liu,

Affiliations Department of Medicine and The Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, United States of America, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Jolanta Idkowiak-Baldys,

Affiliation Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
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Patrick L. Roddy,

Affiliation Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Aleksander Baldys,

Affiliations Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America, Medical and Research Services, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina, United States of America
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John Raymond,

Affiliation Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
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Christopher J. Clarke,

Affiliations Department of Medicine and The Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, United States of America, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Yusuf A. Hannun

* E-mail: yusuf.hannun@sbumed.org

Affiliations Department of Medicine and The Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, United States of America, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯

Sustained Activation of Protein Kinase C Induces Delayed Phosphorylation and Regulates the Fate of Epidermal Growth Factor Receptor

Mengling Liu,
Jolanta Idkowiak-Baldys,
Patrick L. Roddy,
Aleksander Baldys,
John Raymond,
Christopher J. Clarke,
Yusuf A. Hannun

Published: November 11, 2013
https://doi.org/10.1371/journal.pone.0080721

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Transfection
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Endosomes
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Cell membranes
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Endocytosis
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G protein coupled receptors
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