Active Inhibitor-1 Maintains Protein Hyper-Phosphorylation in Aging Hearts and Halts Remodeling in Failing Hearts

• Tracy J. Pritchard ,

  Contributed equally to this work with: Tracy J. Pritchard, Yoshiaki Kawase

  Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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• Yoshiaki Kawase ,

  Contributed equally to this work with: Tracy J. Pritchard, Yoshiaki Kawase

  Affiliation Cardiovascular Research Center, Ichan School of Medicine at Mount Sinai, New York, New York, United States of America

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• Kobra Haghighi,

  Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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• Ahmad Anjak,

  Affiliation Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati, Cincinnati, Ohio, United States of America

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• Wenfeng Cai,

  Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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• Min Jiang,

  Affiliation Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati, Cincinnati, Ohio, United States of America

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• Persoulla Nicolaou,

  Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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• George Pylar,

  Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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• Ioannis Karakikes,

  Affiliation Cardiovascular Research Center, Ichan School of Medicine at Mount Sinai, New York, New York, United States of America

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• Kleopatra Rapti,

  Affiliation Cardiovascular Research Center, Ichan School of Medicine at Mount Sinai, New York, New York, United States of America

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• Jack Rubinstein,

  Affiliation Department of Internal Medicine, Division of Cardiovascular Diseases, University of Cincinnati, Cincinnati, Ohio, United States of America

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• Roger J. Hajjar ,

  ¶RJH and EJK are joint senior co-authors on this work.

  Affiliation Cardiovascular Research Center, Ichan School of Medicine at Mount Sinai, New York, New York, United States of America

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• Evangelia G. Kranias

  * E-mail: litsa.kranias@uc.edu

  ¶RJH and EJK are joint senior co-authors on this work.

  Affiliation Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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