A Novel Antibody Humanization Method Based on Epitopes Scanning and Molecular Dynamics Simulation

Ding Zhang; Cai-Feng Chen; Bin-Bin Zhao; Lu-Lu Gong; Wen-Jing Jin; Jing-Jun Liu; Jing-Fei Wang; Tian-Tian Wang; Xiao-Hui Yuan; You-Wen He

doi:10.1371/journal.pone.0080636

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Open Access

Peer-reviewed

Research Article

A Novel Antibody Humanization Method Based on Epitopes Scanning and Molecular Dynamics Simulation

Ding Zhang ,

Contributed equally to this work with: Ding Zhang, Cai-Feng Chen

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Cai-Feng Chen ,

Contributed equally to this work with: Ding Zhang, Cai-Feng Chen

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Bin-Bin Zhao,

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Lu-Lu Gong,

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Wen-Jing Jin,

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Jing-Jun Liu,

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Jing-Fei Wang,

Affiliation Harbin Veterinary Research Institute, Harbin, Chinese Academy of Agricultural Sciences, Harbin, China
⨯
Tian-Tian Wang,

Affiliation Department of Anesthesiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, China
⨯
Xiao-Hui Yuan ,

* E-mail: youwen.he@duke.edu (YWH); yuanhui1024@gmail.com (XHY)

Affiliation MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
You-Wen He

* E-mail: youwen.he@duke.edu (YWH); yuanhui1024@gmail.com (XHY)

Affiliations MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

A Novel Antibody Humanization Method Based on Epitopes Scanning and Molecular Dynamics Simulation

Ding Zhang,
Cai-Feng Chen,
Bin-Bin Zhao,
Lu-Lu Gong,
Wen-Jing Jin,
Jing-Jun Liu,
Jing-Fei Wang,
Tian-Tian Wang,
Xiao-Hui Yuan,
You-Wen He

Published: November 21, 2013
https://doi.org/10.1371/journal.pone.0080636

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