Novel HCN2 Mutation Contributes to Febrile Seizures by Shifting the Channel's Kinetics in a Temperature-Dependent Manner

• Yuki Nakamura,

  Affiliations Department of Pediatrics, Faculty of Medicine, Fukuoka University, Fukuoka, Japan, The Research Institute for the Molecular Pathomechanisms of Epilepsy, Fukuoka University, Fukuoka, Japan

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• Xiuyu Shi,

  Affiliations The Research Institute for the Molecular Pathomechanisms of Epilepsy, Fukuoka University, Fukuoka, Japan, Department of Pediatrics, Chinese PLA General Hospital, Beijing, China

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• Tomohiro Numata,

  Affiliation Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan

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• Yasuo Mori,

  Affiliation Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan

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• Ryuji Inoue,

  Affiliation Department of Physiology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

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• Christoph Lossin,

  Affiliation Department of Neurology, School of Medicine University of California Davis, Sacramento, California, United States of America

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• Tallie Z. Baram,

  Affiliation Departments of Anatomy & Neurobiology, Pediatrics, and Neurology, University of California Irvine, Irvine, California, United States of America

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• Shinichi Hirose

  * E-mail: hirose@fukuoka-u.ac.jp

  Affiliations Department of Pediatrics, Faculty of Medicine, Fukuoka University, Fukuoka, Japan, The Research Institute for the Molecular Pathomechanisms of Epilepsy, Fukuoka University, Fukuoka, Japan

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