DNase γ Is the Effector Endonuclease for Internucleosomal DNA Fragmentation in Necrosis

Ryushin Mizuta; Shinsuke Araki; Makoto Furukawa; Yuki Furukawa; Syota Ebara; Daisuke Shiokawa; Katsuhiko Hayashi; Sei-ichi Tanuma; Daisuke Kitamura

doi:10.1371/journal.pone.0080223

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Open Access

Peer-reviewed

Research Article

DNase γ Is the Effector Endonuclease for Internucleosomal DNA Fragmentation in Necrosis

Ryushin Mizuta ,

* E-mail: mizuta@rs.noda.tus.ac.jp (RM); kitamura@rs.noda.tus.ac.jp (DK)

Affiliation Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan
⨯
Shinsuke Araki,

Affiliations Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan, Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan
⨯
Makoto Furukawa,

Affiliation Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan
⨯
Yuki Furukawa,

Affiliation Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan
⨯
Syota Ebara,

Affiliation Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan
⨯
Daisuke Shiokawa,

Current address: Division of Cancer Development System, National Cancer Centre Research Institute, Chuo-ku, Tokyo, Japan

Affiliation Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan
⨯
Katsuhiko Hayashi,

Current address: Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-konoe, Sakyo-ku, Japan

Affiliation Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan
⨯
Sei-ichi Tanuma,

Affiliation Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan
⨯
Daisuke Kitamura

* E-mail: mizuta@rs.noda.tus.ac.jp (RM); kitamura@rs.noda.tus.ac.jp (DK)

Affiliations Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan, Department of Molecular Immunology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan
⨯

DNase γ Is the Effector Endonuclease for Internucleosomal DNA Fragmentation in Necrosis

Ryushin Mizuta,
Shinsuke Araki,
Makoto Furukawa,
Yuki Furukawa,
Syota Ebara,
Daisuke Shiokawa,
Katsuhiko Hayashi,
Sei-ichi Tanuma,
Daisuke Kitamura

Published: December 2, 2013
https://doi.org/10.1371/journal.pone.0080223

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Deoxyribonucleases
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Necrosis
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Apoptosis
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DNA electrophoresis
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DNA fragmentation
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Agarose gel electrophoresis
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