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Open Access

Peer-reviewed

Research Article

The Effect of PPE-Induced Emphysema and Chronic LPS-Induced Pulmonary Inflammation on Atherosclerosis Development in APOE3-LEIDEN* Mice

P. Padmini S. J Khedoe ,

Contributed equally to this work with: P. Padmini S. J Khedoe, Man C. Wong

* E-mail: p.p.s.j.khedoe@lumc.nl

Affiliation Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Man C. Wong ,

Contributed equally to this work with: P. Padmini S. J Khedoe, Man C. Wong

Affiliations Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands, Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
⨯
Gerry T. M. Wagenaar,

Affiliation Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Jaap J. Plomp,

Affiliation Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Miranda van Eck,

Affiliation Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
⨯
Louis M. Havekes,

Affiliations Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Organization for Applied Scientific Research, Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands
⨯
Patrick C. N. Rensen,

Affiliations Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
⨯
Pieter S. Hiemstra,

Affiliation Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Jimmy F. P. Berbée

Affiliations Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
⨯

The Effect of PPE-Induced Emphysema and Chronic LPS-Induced Pulmonary Inflammation on Atherosclerosis Development in APOE3-LEIDEN* Mice

P. Padmini S. J Khedoe,
Man C. Wong,
Gerry T. M. Wagenaar,
Jaap J. Plomp,
Miranda van Eck,
Louis M. Havekes,
Patrick C. N. Rensen,
Pieter S. Hiemstra,
Jimmy F. P. Berbée

x

Published: November 26, 2013
https://doi.org/10.1371/journal.pone.0080196

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Atherosclerosis
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Inflammation
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Emphysema
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Chronic obstructive pulmonary disease
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Collagens
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Macrophages
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Cardiovascular diseases
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Safety equipment
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