Streptococcus pneumoniae Serine Protease HtrA, but Not SFP or PrtA, Is a Major Virulence Factor in Pneumonia

Sacha F. de Stoppelaar; Hester J. Bootsma; Aldert Zomer; Joris J. T. H. Roelofs; Peter W. M. Hermans; Cornelis van ’t Veer; Tom van der Poll

doi:10.1371/journal.pone.0080062

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Peer-reviewed

Research Article

Streptococcus pneumoniae Serine Protease HtrA, but Not SFP or PrtA, Is a Major Virulence Factor in Pneumonia

Sacha F. de Stoppelaar ,

* E-mail: s.f.destoppelaar@amc.uva.nl

Affiliations Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Hester J. Bootsma,

Affiliation Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands
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Aldert Zomer,

Affiliations Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands, Center for Molecular and Biomolecular Informatics, Radboud University Medical Center, Nijmegen, The Netherlands
⨯
Joris J. T. H. Roelofs,

Affiliation Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Peter W. M. Hermans,

Affiliation Laboratory of Pediatric Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands
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Cornelis van ’t Veer,

Affiliations Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Tom van der Poll

Affiliations Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯

Streptococcus pneumoniae Serine Protease HtrA, but Not SFP or PrtA, Is a Major Virulence Factor in Pneumonia

Sacha F. de Stoppelaar,
Hester J. Bootsma,
Aldert Zomer,
Joris J. T. H. Roelofs,
Peter W. M. Hermans,
Cornelis van ’t Veer,
Tom van der Poll

Published: November 11, 2013
https://doi.org/10.1371/journal.pone.0080062

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Serine proteases
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