Simvastatin Alleviates Hyperpermeability of Glomerular Endothelial Cells in Early-Stage Diabetic Nephropathy by Inhibition of RhoA/ROCK1

Hui Peng; Pengli Luo; Yuanqing Li; Cheng Wang; Xun Liu; Zengchun Ye; Canming Li; Tanqi Lou

doi:10.1371/journal.pone.0080009

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Open Access

Peer-reviewed

Research Article

Simvastatin Alleviates Hyperpermeability of Glomerular Endothelial Cells in Early-Stage Diabetic Nephropathy by Inhibition of RhoA/ROCK1

Hui Peng ,

Contributed equally to this work with: Hui Peng, Pengli Luo

Affiliation Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China
⨯
Pengli Luo ,

Contributed equally to this work with: Hui Peng, Pengli Luo

Current address: Division of Nephrology, Affiliated Hospital of Qinghai University, Xining, Qinghai, P. R. China

Affiliation Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China
⨯
Yuanqing Li,

Affiliation Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China
⨯
Cheng Wang,

Affiliation Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China
⨯
Xun Liu,

Affiliation Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China
⨯
Zengchun Ye,

Affiliation Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China
⨯
Canming Li,

Affiliation Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China
⨯
Tanqi Lou

* E-mail: lou.tq@163.com

Affiliation Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China
⨯

Simvastatin Alleviates Hyperpermeability of Glomerular Endothelial Cells in Early-Stage Diabetic Nephropathy by Inhibition of RhoA/ROCK1

Hui Peng,
Pengli Luo,
Yuanqing Li,
Cheng Wang,
Xun Liu,
Zengchun Ye,
Canming Li,
Tanqi Lou

Published: November 14, 2013
https://doi.org/10.1371/journal.pone.0080009

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