Salmon and Human Thrombin Differentially Regulate Radicular Pain, Glial-Induced Inflammation and Spinal Neuronal Excitability through Protease-Activated Receptor-1

Jenell R. Smith; Peter P. Syre; Shaina A. Oake; Kristen J. Nicholson; Christine L. Weisshaar; Katrina Cruz; Robert Bucki; Bethany C. Baumann; Paul A. Janmey; Beth A. Winkelstein

doi:10.1371/journal.pone.0080006

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Peer-reviewed

Research Article

Salmon and Human Thrombin Differentially Regulate Radicular Pain, Glial-Induced Inflammation and Spinal Neuronal Excitability through Protease-Activated Receptor-1

Jenell R. Smith,

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Peter P. Syre,

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Shaina A. Oake,

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Kristen J. Nicholson,

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Christine L. Weisshaar,

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Katrina Cruz,

Affiliation Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Robert Bucki,

Affiliation Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Bethany C. Baumann,

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Paul A. Janmey,

Affiliations Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Beth A. Winkelstein

* E-mail: winkelst@seas.upenn.edu

Affiliations Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Salmon and Human Thrombin Differentially Regulate Radicular Pain, Glial-Induced Inflammation and Spinal Neuronal Excitability through Protease-Activated Receptor-1

Jenell R. Smith,
Peter P. Syre,
Shaina A. Oake,
Kristen J. Nicholson,
Christine L. Weisshaar,
Katrina Cruz,
Robert Bucki,
Bethany C. Baumann,
Paul A. Janmey,
Beth A. Winkelstein

Published: November 20, 2013
https://doi.org/10.1371/journal.pone.0080006

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