Multidimensional Single-Cell Analysis of BCR Signaling Reveals Proximal Activation Defect As a Hallmark of Chronic Lymphocytic Leukemia B Cells

• M. Lia Palomba,

  Affiliations Division of Hematology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Center Cancer Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Kelly Piersanti,

  Affiliations Division of Hematology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Center Cancer Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Carly G. K. Ziegler,

  Affiliations Center Cancer Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Program in Computational Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Hugo Decker,

  Affiliations Center Cancer Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Program in Computational Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Jesse W. Cotari,

  Affiliations Center Cancer Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Program in Computational Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Kurt Bantilan,

  Affiliation Division of Hematology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Ivelise Rijo,

  Affiliation Division of Hematology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Jeff R. Gardner,

  Affiliation Division of Hematology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Mark Heaney,

  Affiliation Division of Hematology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Debra Bemis,

  Affiliations Center Cancer Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Program in Computational Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Robert Balderas,

  Affiliation BD Biosciences, San Diego, California, United States of America

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• Sami N. Malek,

  Affiliation Division of Hematology/Oncology, University of Michigan Health System, Ann Harbor, Michigan, United States of America

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• Erlene Seymour,

  Affiliation Division of Hematology/Oncology, University of Michigan Health System, Ann Harbor, Michigan, United States of America

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• Andrew D. Zelenetz,

  Affiliation Division of Hematology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Marcel R. M. van den Brink ,

  Contributed equally to this work with: Marcel R. M. van den Brink, Grégoire Altan-Bonnet

  * E-mail: m-van-den-brink@ski.mskcc.org (MB); altanbog@mskcc.org (GA)

  Affiliation Division of Hematology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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•  [ ... ],
• Grégoire Altan-Bonnet

  Contributed equally to this work with: Marcel R. M. van den Brink, Grégoire Altan-Bonnet

  * E-mail: m-van-den-brink@ski.mskcc.org (MB); altanbog@mskcc.org (GA)

  Affiliations Center Cancer Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Program in Computational Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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