Lincomycin Biosynthesis Involves a Tyrosine Hydroxylating Heme Protein of an Unusual Enzyme Family

Jitka Novotna; Jana Olsovska; Petr Novak; Peter Mojzes; Radka Chaloupkova; Zdenek Kamenik; Jaroslav Spizek; Eva Kutejova; Marketa Mareckova; Pavel Tichy; Jiri Damborsky; Jiri Janata

doi:10.1371/journal.pone.0079974

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Open Access

Peer-reviewed

Research Article

Lincomycin Biosynthesis Involves a Tyrosine Hydroxylating Heme Protein of an Unusual Enzyme Family

Jitka Novotna ,

* E-mail: jinov1@mail.muni.cz

Affiliations Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic, Central-European Technology Institute, Brno, Czech Republic, Crop Research Institute, Drnovska Prague, Czech Republic
⨯
Jana Olsovska,

Current address: Research Institute of Brewing and Malting, Prague, Czech Republic

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Petr Novak,

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Peter Mojzes,

Affiliation Institute of Physics, Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic
⨯
Radka Chaloupkova,

Affiliation Loschmidt Laboratories, Institute of Experimental Biology and National Centre for Biomolecular Research, Brno, Czech Republic
⨯
Zdenek Kamenik,

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Jaroslav Spizek,

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Eva Kutejova,

Affiliations Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic, Institute of Molecular Biology, Slovak Academy of Sciences, Bratislava, Slovak Republic
⨯
Marketa Mareckova,

Affiliation Crop Research Institute, Drnovska Prague, Czech Republic
⨯
Pavel Tichy,

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Jiri Damborsky,

Affiliation Loschmidt Laboratories, Institute of Experimental Biology and National Centre for Biomolecular Research, Brno, Czech Republic
⨯
Jiri Janata

Affiliation Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯

Lincomycin Biosynthesis Involves a Tyrosine Hydroxylating Heme Protein of an Unusual Enzyme Family

Jitka Novotna,
Jana Olsovska,
Petr Novak,
Peter Mojzes,
Radka Chaloupkova,
Zdenek Kamenik,
Jaroslav Spizek,
Eva Kutejova,
Marketa Mareckova,
Pavel Tichy

Published: December 4, 2013
https://doi.org/10.1371/journal.pone.0079974

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Heme
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Tyrosine
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Peroxidases
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Biochemical cofactors
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Biosynthesis
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Enzymes
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Hydroxylation
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Prosthetic groups
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