Phenotypic and Transcriptional Fidelity of Patient-Derived Colon Cancer Xenografts in Immune-Deficient Mice

Jeffrey Chou; Matthew P. Fitzgibbon; Christie-Lynn L. Mortales; Andrea M. H. Towlerton; Melissa P. Upton; Raymond S. Yeung; Martin W. McIntosh; Edus H. Warren

doi:10.1371/journal.pone.0079874

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Open Access

Peer-reviewed

Research Article

Phenotypic and Transcriptional Fidelity of Patient-Derived Colon Cancer Xenografts in Immune-Deficient Mice

Jeffrey Chou ,

* E-mail: jchou2@uw.edu (JC); ehwarren@u.washington.edu (EW)

Affiliations Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Division of Medical Oncology, Department of Medicine, University of Washington Medical Center, Seattle, Washington, United States of America
⨯
Matthew P. Fitzgibbon,

Affiliation Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Christie-Lynn L. Mortales,

Affiliation Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Andrea M. H. Towlerton,

Affiliation Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Melissa P. Upton,

Affiliation Gastrointestinal and Liver Pathology Service, Department of Pathology, University of Washington, Seattle, Washington, United States of America
⨯
Raymond S. Yeung,

Affiliation Department of Surgery, University of Washington, Seattle, Washington, United States of America
⨯
Martin W. McIntosh,

Affiliation Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Edus H. Warren

* E-mail: jchou2@uw.edu (JC); ehwarren@u.washington.edu (EW)

Affiliations Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Division of Medical Oncology, Department of Medicine, University of Washington Medical Center, Seattle, Washington, United States of America
⨯

Phenotypic and Transcriptional Fidelity of Patient-Derived Colon Cancer Xenografts in Immune-Deficient Mice

Jeffrey Chou,
Matthew P. Fitzgibbon,
Christie-Lynn L. Mortales,
Andrea M. H. Towlerton,
Melissa P. Upton,
Raymond S. Yeung,
Martin W. McIntosh,
Edus H. Warren

Published: November 20, 2013
https://doi.org/10.1371/journal.pone.0079874

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