Addition of Exogenous NAD⁺ Prevents Mefloquine-Induced Neuroaxonal and Hair Cell Degeneration through Reduction of Caspase-3-Mediated Apoptosis in Cochlear Organotypic Cultures

• Dalian Ding,

  Affiliations Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York, United States of America, Sixth People’s Hospital, Shanghai Oriental Otolaryngology Institute, Shanghai Jiao Tong University, Shanghai, China, Xiangya Hospital, Central South University, Changsha, Hunan, China, Department of Applied Biological Chemistry, University of Tokyo, Yayoi, Tokyo, Japan

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• Weidong Qi,

  Affiliation Department of Otolaryngology-Head and Neck Surgery, Huashan Hospital, Fudan University, Shanghai, China

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• Dongzhen Yu,

  Affiliation Sixth People’s Hospital, Shanghai Oriental Otolaryngology Institute, Shanghai Jiao Tong University, Shanghai, China

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• Haiyan Jiang,

  Affiliation Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York, United States of America

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• Chul Han,

  Affiliation Departments of Aging and Geriatric Research, Division of Biology of Aging, University of Florida, Gainesville, Florida, United States of America

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• Mi-Jung Kim,

  Affiliation Departments of Aging and Geriatric Research, Division of Biology of Aging, University of Florida, Gainesville, Florida, United States of America

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• Kana Katsuno,

  Affiliation Department of Applied Biological Chemistry, University of Tokyo, Yayoi, Tokyo, Japan

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• Yun Hua Hsieh,

  Affiliation Department of Applied Biological Chemistry, University of Tokyo, Yayoi, Tokyo, Japan

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• Takuya Miyakawa,

  Affiliation Department of Applied Biological Chemistry, University of Tokyo, Yayoi, Tokyo, Japan

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• Richard Salvi,

  Affiliation Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York, United States of America

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• Masaru Tanokura ,

  * E-mail: amtanok@mail.ecc.u-tokyo.ac.jp (MT); someya@ufl.edu (SS)

  Affiliation Department of Applied Biological Chemistry, University of Tokyo, Yayoi, Tokyo, Japan

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• Shinichi Someya

  * E-mail: amtanok@mail.ecc.u-tokyo.ac.jp (MT); someya@ufl.edu (SS)

  Affiliation Departments of Aging and Geriatric Research, Division of Biology of Aging, University of Florida, Gainesville, Florida, United States of America

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