Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies

Cordelia Ziraldo; Yoram Vodovotz; Rami A. Namas; Khalid Almahmoud; Victor Tapias; Qi Mi; Derek Barclay; Bahiyyah S. Jefferson; Guoqiang Chen; Timothy R. Billiar; Ruben Zamora

doi:10.1371/journal.pone.0079804

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Peer-reviewed

Research Article

Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies

Cordelia Ziraldo ,

Contributed equally to this work with: Cordelia Ziraldo, Yoram Vodovotz

Affiliations Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Joint Carnegie Mellon University – University of Pittsburgh Ph.D. Program in Computational Biology, Pittsburgh, Pennsylvania, United States of America
⨯
Yoram Vodovotz ,

Contributed equally to this work with: Cordelia Ziraldo, Yoram Vodovotz

Affiliations Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Rami A. Namas,

Affiliation Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Khalid Almahmoud,

Affiliation Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Victor Tapias,

Affiliation Department of Neurology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Qi Mi,

Affiliations Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania, United States of America, Sports Medicine and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Derek Barclay,

Affiliation Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Bahiyyah S. Jefferson,

Affiliation Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Guoqiang Chen,

Affiliations Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Anesthesiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
⨯
Timothy R. Billiar,

Affiliations Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Ruben Zamora

* E-mail: zamorar@pitt.edu

Affiliations Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania, United States of America
⨯

Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies

Cordelia Ziraldo,
Yoram Vodovotz,
Rami A. Namas,
Khalid Almahmoud,
Victor Tapias,
Qi Mi,
Derek Barclay,
Bahiyyah S. Jefferson,
Guoqiang Chen,
Timothy R. Billiar

Published: December 3, 2013
https://doi.org/10.1371/journal.pone.0079804

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