Lifelong Obesity in a Polygenic Mouse Model Prevents Age- and Diet-Induced Glucose Intolerance– Obesity Is No Road to Late-Onset Diabetes in Mice

Ulla Renne; Martina Langhammer; Julia Brenmoehl; Christina Walz; Anja Zeissler; Armin Tuchscherer; Marion Piechotta; Rudolf J. Wiesner; Maximilian Bielohuby; Andreas Hoeflich

doi:10.1371/journal.pone.0079788

Loading metrics

Open Access

Peer-reviewed

Research Article

Lifelong Obesity in a Polygenic Mouse Model Prevents Age- and Diet-Induced Glucose Intolerance– Obesity Is No Road to Late-Onset Diabetes in Mice

Ulla Renne ,

Contributed equally to this work with: Ulla Renne, Martina Langhammer

Affiliation Laboratory for Mouse Genetics, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
⨯
Martina Langhammer ,

Contributed equally to this work with: Ulla Renne, Martina Langhammer

Affiliation Laboratory for Mouse Genetics, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
⨯
Julia Brenmoehl,

Affiliations Laboratory for Mouse Genetics, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany, Cell Signaling Unit, Institute for Genome Biology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
⨯
Christina Walz,

Affiliations Laboratory for Mouse Genetics, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany, Cell Signaling Unit, Institute for Genome Biology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
⨯
Anja Zeissler,

Affiliations Laboratory for Mouse Genetics, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany, Cell Signaling Unit, Institute for Genome Biology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
⨯
Armin Tuchscherer,

Affiliation Livestock Genetics and Breeding Unit, Institute for Genetics & Biometry, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
⨯
Marion Piechotta,

Affiliation Clinic for Cattle, University of Veterinary Medicine, Hannover, Germany
⨯
Rudolf J. Wiesner,

Affiliations Center for Physiology and Pathophysiology, Institute of Vegetative Physiology, University of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases, University of Cologne, Cologne, Germany
⨯
Maximilian Bielohuby,

Affiliation Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Munich, Germany
⨯
Andreas Hoeflich

* E-mail: hoeflich@fbn-dummerstorf.de

Affiliations Laboratory for Mouse Genetics, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany, Cell Signaling Unit, Institute for Genome Biology, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
⨯

Lifelong Obesity in a Polygenic Mouse Model Prevents Age- and Diet-Induced Glucose Intolerance– Obesity Is No Road to Late-Onset Diabetes in Mice

Ulla Renne,
Martina Langhammer,
Julia Brenmoehl,
Christina Walz,
Anja Zeissler,
Armin Tuchscherer,
Marion Piechotta,
Rudolf J. Wiesner,
Maximilian Bielohuby,
Andreas Hoeflich

Published: November 13, 2013
https://doi.org/10.1371/journal.pone.0079788

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Obesity
Is the Subject Area "Obesity" applicable to this article?

Thanks for your feedback.
Diet
Is the Subject Area "Diet" applicable to this article?

Thanks for your feedback.
Glucose intolerance
Is the Subject Area "Glucose intolerance" applicable to this article?

Thanks for your feedback.
Fats
Is the Subject Area "Fats" applicable to this article?

Thanks for your feedback.
Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
Food
Is the Subject Area "Food" applicable to this article?

Thanks for your feedback.
Adipose tissue
Is the Subject Area "Adipose tissue" applicable to this article?

Thanks for your feedback.