Bi-Factor Analysis Based on Noise-Reduction (BIFANR): A New Algorithm for Detecting Coevolving Amino Acid Sites in Proteins

Open Access

Peer-reviewed

Research Article

Juntao Liu ,

Contributed equally to this work with: Juntao Liu, Xiaoyun Duan

Affiliation School of Mathematics, Shandong University, Jinan, China
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Xiaoyun Duan ,

Contributed equally to this work with: Juntao Liu, Xiaoyun Duan

Affiliation School of Life Science, Shandong University, Jinan, China
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Jianyang Sun,

Affiliation School of Mathematics, Shandong University, Jinan, China
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Yanbin Yin,

Affiliation Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois, United States of America
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Guojun Li,

Affiliation School of Mathematics, Shandong University, Jinan, China
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Lushan Wang,

Affiliation School of Life Science, Shandong University, Jinan, China
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Bingqiang Liu

* E-mail: Bingqiang Liu: bingqiang@sdu.edu.cn

Affiliation School of Mathematics, Shandong University, Jinan, China
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Amino acid analysis
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Molecular evolution
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Entropy
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Evolutionary rate
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Eigenvectors
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Algorithms
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Protein structure
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Noise reduction
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