Hyperglycemia Enhances the Proliferation of Non-Tumorigenic and Malignant Mammary Epithelial Cells through Increased leptin/IGF1R Signaling and Activation of AKT/mTOR

Rebecca Lopez; Arunkumar Arumugam; Riya Joseph; Kanika Monga; Thiyagarajan Boopalan; Pamela Agullo; Christina Gutierrez; Sushmita Nandy; Ramadevi Subramani; Jose Manuel de la Rosa; Rajkumar Lakshmanaswamy

doi:10.1371/journal.pone.0079708

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Open Access

Peer-reviewed

Research Article

Hyperglycemia Enhances the Proliferation of Non-Tumorigenic and Malignant Mammary Epithelial Cells through Increased leptin/IGF1R Signaling and Activation of AKT/mTOR

Rebecca Lopez,

Affiliation Center of Excellence in Cancer Research, Center of Excellence in Diabetes Research, Department of Biomedical Sciences MSB1, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America
⨯
Arunkumar Arumugam,

Affiliation Center of Excellence in Cancer Research, Center of Excellence in Diabetes Research, Department of Biomedical Sciences MSB1, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America
⨯
Riya Joseph,

Affiliation Center of Excellence in Cancer Research, Center of Excellence in Diabetes Research, Department of Biomedical Sciences MSB1, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America
⨯
Kanika Monga,

Affiliation Center of Excellence in Cancer Research, Center of Excellence in Diabetes Research, Department of Biomedical Sciences MSB1, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America
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Thiyagarajan Boopalan,

Affiliation Center of Excellence in Cancer Research, Center of Excellence in Diabetes Research, Department of Biomedical Sciences MSB1, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America
⨯
Pamela Agullo,

Affiliation Center of Excellence in Cancer Research, Center of Excellence in Diabetes Research, Department of Biomedical Sciences MSB1, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America
⨯
Christina Gutierrez,

Affiliation Center of Excellence in Cancer Research, Center of Excellence in Diabetes Research, Department of Biomedical Sciences MSB1, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America
⨯
Sushmita Nandy,

Affiliation Center of Excellence in Cancer Research, Center of Excellence in Diabetes Research, Department of Biomedical Sciences MSB1, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America
⨯
Ramadevi Subramani,

Affiliation Center of Excellence in Cancer Research, Center of Excellence in Diabetes Research, Department of Biomedical Sciences MSB1, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America
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Jose Manuel de la Rosa,

Affiliation Center of Excellence in Cancer Research, Center of Excellence in Diabetes Research, Department of Biomedical Sciences MSB1, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America
⨯
Rajkumar Lakshmanaswamy

* E-mail: rajkumar.lakshmanaswamy@ttuhsc.edu

Affiliation Center of Excellence in Cancer Research, Center of Excellence in Diabetes Research, Department of Biomedical Sciences MSB1, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America
⨯

Hyperglycemia Enhances the Proliferation of Non-Tumorigenic and Malignant Mammary Epithelial Cells through Increased leptin/IGF1R Signaling and Activation of AKT/mTOR

Rebecca Lopez,
Arunkumar Arumugam,
Riya Joseph,
Kanika Monga,
Thiyagarajan Boopalan,
Pamela Agullo,
Christina Gutierrez,
Sushmita Nandy,
Ramadevi Subramani,
Jose Manuel de la Rosa

Published: November 18, 2013
https://doi.org/10.1371/journal.pone.0079708

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Breast cancer
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Leptin
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Glucose
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Glucose signaling
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Cell proliferation
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