Eicosanoid Profiling in an Orthotopic Model of Lung Cancer Progression by Mass Spectrometry Demonstrates Selective Production of Leukotrienes by Inflammatory Cells of the Microenvironment

Joanna M. Poczobutt; Miguel Gijon; Jay Amin; Dwight Hanson; Howard Li; Deandra Walker; Mary Weiser-Evans; Xian Lu; Robert C. Murphy; Raphael A. Nemenoff

doi:10.1371/journal.pone.0079633

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Open Access

Peer-reviewed

Research Article

Eicosanoid Profiling in an Orthotopic Model of Lung Cancer Progression by Mass Spectrometry Demonstrates Selective Production of Leukotrienes by Inflammatory Cells of the Microenvironment

Joanna M. Poczobutt,

Affiliation Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
⨯
Miguel Gijon,

Affiliation Department of Pharmacology, University of Colorado Denver, Aurora, Colorado, United States of America
⨯
Jay Amin,

Affiliation Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
⨯
Dwight Hanson,

Affiliation Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
⨯
Howard Li,

Affiliations Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America, Veterans Affairs Medical Center, Denver, Colorado, United States of America
⨯
Deandra Walker,

Affiliation Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
⨯
Mary Weiser-Evans,

Affiliation Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
⨯
Xian Lu,

Affiliation Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, United States of America
⨯
Robert C. Murphy,

Affiliation Department of Pharmacology, University of Colorado Denver, Aurora, Colorado, United States of America
⨯
Raphael A. Nemenoff

* E-mail: Raphael.Nemenoff@ucdenver.edu

Affiliations Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America, Department of Pharmacology, University of Colorado Denver, Aurora, Colorado, United States of America
⨯

Eicosanoid Profiling in an Orthotopic Model of Lung Cancer Progression by Mass Spectrometry Demonstrates Selective Production of Leukotrienes by Inflammatory Cells of the Microenvironment

Joanna M. Poczobutt,
Miguel Gijon,
Jay Amin,
Dwight Hanson,
Howard Li,
Deandra Walker,
Mary Weiser-Evans,
Xian Lu,
Robert C. Murphy,
Raphael A. Nemenoff

Published: November 11, 2013
https://doi.org/10.1371/journal.pone.0079633

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Lung and intrathoracic tumors
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Eicosanoids
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Secondary lung tumors
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Mouse models
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Inflammation
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Non-small cell lung cancer
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Flow cytometry
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