Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhances Induction of Apoptosis

Open Access

Peer-reviewed

Research Article

Tetsuya Kurosu,

Affiliation Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
⨯
Toshikage Nagao,

Affiliation Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
⨯
Nan Wu,

Affiliation Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
⨯
Gaku Oshikawa,

Affiliation Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
⨯
Osamu Miura

* E-mail: miura.hema@tmd.ac.jp

Affiliation Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
⨯

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Apoptosis
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Tyrosine kinases
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Flow cytometry
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Phosphorylation
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DNA damage
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Chemotherapy
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Signal inhibition
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