Impaired Spatial Learning and Memory after Sevoflurane–Nitrous Oxide Anesthesia in Aged Rats Is Associated with Down-Regulated cAMP/CREB Signaling

• Wan-Xia Xiong ,

  Contributed equally to this work with: Wan-Xia Xiong, Guo-Xia Zhou

  Affiliation Department of Anesthesia, Zhongshan Hospital and Department of Anesthesiology, Shanghai Medical College, Fudan University, Shanghai, China

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• Guo-Xia Zhou ,

  Contributed equally to this work with: Wan-Xia Xiong, Guo-Xia Zhou

  Affiliation Department of Anesthesia, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China

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• Bei Wang,

  Affiliation Department of Anesthesia, Zhongshan Hospital and Department of Anesthesiology, Shanghai Medical College, Fudan University, Shanghai, China

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• Zhang-Gang Xue,

  Affiliation Department of Anesthesia, Zhongshan Hospital and Department of Anesthesiology, Shanghai Medical College, Fudan University, Shanghai, China

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• Lu Wang,

  Affiliation Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China

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• Hui-Chuan Sun,

  Affiliation Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China

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• Sheng-Jin Ge

  * E-mail: ge.shengjin@fudan.edu.cn

  Affiliation Department of Anesthesia, Zhongshan Hospital and Department of Anesthesiology, Shanghai Medical College, Fudan University, Shanghai, China

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