Circulating CD4+CD161+ T Lymphocytes Are Increased in Seropositive Arthralgia Patients but Decreased in Patients with Newly Diagnosed Rheumatoid Arthritis

Paulina Chalan; Bart-Jan Kroesen; Kornelis S. M. van der Geest; Minke G. Huitema; Wayel H. Abdulahad; Johan Bijzet; Elisabeth Brouwer; Annemieke M. H. Boots

doi:10.1371/journal.pone.0079370

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Peer-reviewed

Research Article

Circulating CD4+CD161+ T Lymphocytes Are Increased in Seropositive Arthralgia Patients but Decreased in Patients with Newly Diagnosed Rheumatoid Arthritis

Paulina Chalan,

Affiliations Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands, Groningen research initiative on healthy ageing and immune longevity (GRAIL), Groningen, The Netherlands
⨯
Bart-Jan Kroesen ,

Contributed equally to this work with: Bart-Jan Kroesen, Kornelis S. M. van der Geest

Affiliations Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands, Groningen research initiative on healthy ageing and immune longevity (GRAIL), Groningen, The Netherlands
⨯
Kornelis S. M. van der Geest ,

Contributed equally to this work with: Bart-Jan Kroesen, Kornelis S. M. van der Geest

Affiliations Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands, Groningen research initiative on healthy ageing and immune longevity (GRAIL), Groningen, The Netherlands
⨯
Minke G. Huitema,

Affiliations Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands, Groningen research initiative on healthy ageing and immune longevity (GRAIL), Groningen, The Netherlands
⨯
Wayel H. Abdulahad,

Affiliations Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands, Groningen research initiative on healthy ageing and immune longevity (GRAIL), Groningen, The Netherlands
⨯
Johan Bijzet,

Affiliations Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands, Groningen research initiative on healthy ageing and immune longevity (GRAIL), Groningen, The Netherlands
⨯
Elisabeth Brouwer,

Affiliations Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands, Groningen research initiative on healthy ageing and immune longevity (GRAIL), Groningen, The Netherlands
⨯
Annemieke M. H. Boots

* E-mail: m.boots@umcg.nl

Affiliations Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands, Groningen research initiative on healthy ageing and immune longevity (GRAIL), Groningen, The Netherlands
⨯

Circulating CD4+CD161+ T Lymphocytes Are Increased in Seropositive Arthralgia Patients but Decreased in Patients with Newly Diagnosed Rheumatoid Arthritis

Paulina Chalan,
Bart-Jan Kroesen,
Kornelis S. M. van der Geest,
Minke G. Huitema,
Wayel H. Abdulahad,
Johan Bijzet,
Elisabeth Brouwer,
Annemieke M. H. Boots

Published: November 1, 2013
https://doi.org/10.1371/journal.pone.0079370

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T cells
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Arthralgia
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C-reactive proteins
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Synovial fluid
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