Unexpected CEP290 mRNA Splicing in a Humanized Knock-In Mouse Model for Leber Congenital Amaurosis

Alejandro Garanto; Sylvia E. C. van Beersum; Theo A. Peters; Ronald Roepman; Frans P. M. Cremers; Rob W. J. Collin

doi:10.1371/journal.pone.0079369

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Peer-reviewed

Research Article

Unexpected CEP290 mRNA Splicing in a Humanized Knock-In Mouse Model for Leber Congenital Amaurosis

Alejandro Garanto,

Affiliations Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands, Institute for Genetic and Metabolic Disease, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Sylvia E. C. van Beersum,

Affiliations Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands, Institute for Genetic and Metabolic Disease, Radboud University Medical Centre, Nijmegen, The Netherlands, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Theo A. Peters,

Affiliations Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands, Department of Otorhinolaryngology, Head and Neck Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Ronald Roepman,

Affiliations Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands, Institute for Genetic and Metabolic Disease, Radboud University Medical Centre, Nijmegen, The Netherlands, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Frans P. M. Cremers,

Affiliations Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Rob W. J. Collin

* E-mail: rob.collin@radboudumc.nl

Affiliations Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands, Institute for Genetic and Metabolic Disease, Radboud University Medical Centre, Nijmegen, The Netherlands, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯

Unexpected CEP290 mRNA Splicing in a Humanized Knock-In Mouse Model for Leber Congenital Amaurosis

Alejandro Garanto,
Sylvia E. C. van Beersum,
Theo A. Peters,
Ronald Roepman,
Frans P. M. Cremers,
Rob W. J. Collin

Published: November 6, 2013
https://doi.org/10.1371/journal.pone.0079369

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