ADAM17-Mediated Processing of TNF-α Expressed by Antiviral Effector CD8+ T Cells Is Required for Severe T-Cell-Mediated Lung Injury

Open Access

Peer-reviewed

Research Article

ADAM17-Mediated Processing of TNF-α Expressed by Antiviral Effector CD8⁺ T Cells Is Required for Severe T-Cell-Mediated Lung Injury

Matthew P. DeBerge ,

* E-mail: matthew.deberge@dartmouth.edu

Affiliation Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
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Kenneth H. Ely,

Affiliation Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
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Guang-Shing Cheng,

Affiliation Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America
⨯
Richard I. Enelow

Affiliations Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America, Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America
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T cells
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Cytotoxic T cells
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Mouse models
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Genetically modified animals
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Epithelial cells
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Influenza
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Neutrophils
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Chemokines
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