Panobinostat Enhances Cytarabine and Daunorubicin Sensitivities in AML Cells through Suppressing the Expression of BRCA1, CHK1, and Rad51

Chengzhi Xie; Christina Drenberg; Holly Edwards; J. Timothy Caldwell; Wei Chen; Hiroto Inaba; Xuelian Xu; Steven A. Buck; Jeffrey W. Taub; Sharyn D. Baker; Yubin Ge

doi:10.1371/journal.pone.0079106

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Peer-reviewed

Research Article

Panobinostat Enhances Cytarabine and Daunorubicin Sensitivities in AML Cells through Suppressing the Expression of BRCA1, CHK1, and Rad51

Chengzhi Xie ,

Contributed equally to this work with: Chengzhi Xie, Christina Drenberg

Affiliations Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America, The State Engineering Laboratory of AIDS Vaccine, College of Life Science, Jilin University, Changchun, China
⨯
Christina Drenberg ,

Contributed equally to this work with: Chengzhi Xie, Christina Drenberg

Affiliation Pharmaceutical Sciences Department, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Holly Edwards,

Affiliations Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
J. Timothy Caldwell,

Affiliations MD/PhD Program, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Cancer Biology Program, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Wei Chen,

Affiliation Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Hiroto Inaba,

Affiliation Department of Oncology, Division of Leukemia/Lymphoma, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Xuelian Xu,

Affiliations Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Steven A. Buck,

Affiliation Division of Pediatric Hematology/Oncology, Children’s Hospital of Michigan, Detroit, Michigan, United States of America
⨯
Jeffrey W. Taub,

Affiliations Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Division of Pediatric Hematology/Oncology, Children’s Hospital of Michigan, Detroit, Michigan, United States of America, Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Sharyn D. Baker,

Affiliation Pharmaceutical Sciences Department, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Yubin Ge

* E-mail: gey@karmanos.org

Affiliations Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America, The State Engineering Laboratory of AIDS Vaccine, College of Life Science, Jilin University, Changchun, China
⨯

Panobinostat Enhances Cytarabine and Daunorubicin Sensitivities in AML Cells through Suppressing the Expression of BRCA1, CHK1, and Rad51

Chengzhi Xie,
Christina Drenberg,
Holly Edwards,
J. Timothy Caldwell,
Wei Chen,
Hiroto Inaba,
Xuelian Xu,
Steven A. Buck,
Jeffrey W. Taub,
Sharyn D. Baker

Published: November 11, 2013
https://doi.org/10.1371/journal.pone.0079106

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