Targeting JNK by a New Curcumin Analog to Inhibit NF-kB-Mediated Expression of Cell Adhesion Molecules Attenuates Renal Macrophage Infiltration and Injury in Diabetic Mice

Yong Pan; Xiuhua Zhang; Yi Wang; Lu Cai; Luqing Ren; Longguang Tang; Jingying Wang; Yunjie Zhao; Yonggang Wang; Quan Liu; Xiaokun Li; Guang Liang

doi:10.1371/journal.pone.0079084

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Open Access

Peer-reviewed

Research Article

Targeting JNK by a New Curcumin Analog to Inhibit NF-kB-Mediated Expression of Cell Adhesion Molecules Attenuates Renal Macrophage Infiltration and Injury in Diabetic Mice

Yong Pan ,

Contributed equally to this work with: Yong Pan, Xiuhua Zhang, Yi Wang

Affiliations Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China, Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Xiuhua Zhang ,

Contributed equally to this work with: Yong Pan, Xiuhua Zhang, Yi Wang

Affiliation Department of Pharmacy, The 1st Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Yi Wang ,

Contributed equally to this work with: Yong Pan, Xiuhua Zhang, Yi Wang

Affiliation Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Lu Cai,

Affiliations Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, Zhejiang, China, Department of Pediatrics, University of Louisville, Louisville, Kentucky, United States of America
⨯
Luqing Ren,

Affiliation Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Longguang Tang,

Affiliation Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Jingying Wang,

Affiliation Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Yunjie Zhao,

Affiliation Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Yonggang Wang,

Affiliations Department of Pediatrics, University of Louisville, Louisville, Kentucky, United States of America, Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin, China
⨯
Quan Liu,

Affiliations Department of Pediatrics, University of Louisville, Louisville, Kentucky, United States of America, Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin, China
⨯
Xiaokun Li,

Affiliations Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China, Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Guang Liang

* E-mail: wzmcliangguang@163.com

Affiliation Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯

Targeting JNK by a New Curcumin Analog to Inhibit NF-kB-Mediated Expression of Cell Adhesion Molecules Attenuates Renal Macrophage Infiltration and Injury in Diabetic Mice

Yong Pan,
Xiuhua Zhang,
Yi Wang,
Lu Cai,
Luqing Ren,
Longguang Tang,
Jingying Wang,
Yunjie Zhao,
Yonggang Wang,
Quan Liu

Published: November 18, 2013
https://doi.org/10.1371/journal.pone.0079084

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