The Tumor Targeted Superantigen ABR-217620 Selectively Engages TRBV7-9 and Exploits TCR-pMHC Affinity Mimicry in Mediating T Cell Cytotoxicity

Open Access

Peer-reviewed

Research Article

Gunnar Hedlund ,

* E-mail: gunnar.hedlund@activebiotech.com

Affiliation Active Biotech AB, Lund, Sweden
⨯
Helena Eriksson,

Affiliation Active Biotech AB, Lund, Sweden
⨯
Anette Sundstedt,

Affiliation Active Biotech AB, Lund, Sweden
⨯
Göran Forsberg,

Affiliation Active Biotech AB, Lund, Sweden
⨯
Bent K. Jakobsen,

Affiliation Immunocore Ltd., Oxon, United Kingdom
⨯
Nicholas Pumphrey,

Affiliation Adaptimmune Ltd., Oxon, United Kingdom
⨯
Karin Rödström,

Affiliation Experimental Medical Science, Lund University, Lund, Sweden
⨯
Karin Lindkvist-Petersson,

Affiliation Experimental Medical Science, Lund University, Lund, Sweden
⨯
Per Björk

Affiliation Active Biotech AB, Lund, Sweden
⨯

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T cells
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Major histocompatibility complex
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Cell binding
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Cancers and neoplasms
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Renal cancer
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Cell fusion
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Binding analysis
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Non-small cell lung cancer
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