Acute Lung Injury and Acute Kidney Injury Are Established by Four Hours in Experimental Sepsis and Are Improved with Pre, but Not Post, Sepsis Administration of TNF-α Antibodies

Rhea Bhargava; Christopher J. Altmann; Ana Andres-Hernando; Ryan G. Webb; Kayo Okamura; Yimu Yang; Sandor Falk; Eric P. Schmidt; Sarah Faubel

doi:10.1371/journal.pone.0079037

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Research Article

Acute Lung Injury and Acute Kidney Injury Are Established by Four Hours in Experimental Sepsis and Are Improved with Pre, but Not Post, Sepsis Administration of TNF-α Antibodies

Rhea Bhargava ,

Contributed equally to this work with: Rhea Bhargava, Christopher J. Altmann, Ana Andres-Hernando

Affiliation Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
Christopher J. Altmann ,

Contributed equally to this work with: Rhea Bhargava, Christopher J. Altmann, Ana Andres-Hernando

Affiliation Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
Ana Andres-Hernando ,

Contributed equally to this work with: Rhea Bhargava, Christopher J. Altmann, Ana Andres-Hernando

Affiliation Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
Ryan G. Webb,

Affiliation Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
Kayo Okamura,

Affiliation Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
Yimu Yang,

Affiliation Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Aurora, Colorado, United States of America
⨯
Sandor Falk,

Affiliation Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
Eric P. Schmidt,

Affiliation Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Aurora, Colorado, United States of America
⨯
Sarah Faubel

* E-mail: sarah.faubel@ucdenver.edu

Affiliation Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯

Acute Lung Injury and Acute Kidney Injury Are Established by Four Hours in Experimental Sepsis and Are Improved with Pre, but Not Post, Sepsis Administration of TNF-α Antibodies

Rhea Bhargava,
Christopher J. Altmann,
Ana Andres-Hernando,
Ryan G. Webb,
Kayo Okamura,
Yimu Yang,
Sandor Falk,
Eric P. Schmidt,
Sarah Faubel

Published: November 12, 2013
https://doi.org/10.1371/journal.pone.0079037

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