Single Intraperitoneal Injection of Monocrotaline as a Novel Large Animal Model of Chronic Pulmonary Hypertension in Tibet Minipigs

Guang-qiao Zeng; Rong Liu; Hai-xing Liao; Xin-feng Zhang; Yuan-xin Qian; Bao-hua Liu; Qing-hong Wu; Jin Zhao; Wei-wang Gu; Hong-tao Li

doi:10.1371/journal.pone.0078965

Loading metrics

Open Access

Peer-reviewed

Research Article

Single Intraperitoneal Injection of Monocrotaline as a Novel Large Animal Model of Chronic Pulmonary Hypertension in Tibet Minipigs

Guang-qiao Zeng,

Affiliations First Affiliated Hospital, Guangzhou Medical University; Guangzhou, Guangdong, China, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Rong Liu,

Affiliations First Affiliated Hospital, Guangzhou Medical University; Guangzhou, Guangdong, China, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Hai-xing Liao,

Affiliation First Affiliated Hospital, Guangzhou Medical University; Guangzhou, Guangdong, China
⨯
Xin-feng Zhang,

Affiliation First Affiliated Hospital, Guangzhou Medical University; Guangzhou, Guangdong, China
⨯
Yuan-xin Qian,

Affiliation First Affiliated Hospital, Guangzhou Medical University; Guangzhou, Guangdong, China
⨯
Bao-hua Liu,

Affiliation First Affiliated Hospital, Guangzhou Medical University; Guangzhou, Guangdong, China
⨯
Qing-hong Wu,

Affiliation Laboratory Animal Centre, Southern Medical University, Guangzhou, Guangdong, China
⨯
Jin Zhao,

Affiliations First Affiliated Hospital, Guangzhou Medical University; Guangzhou, Guangdong, China, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China
⨯
Wei-wang Gu,

Affiliation Laboratory Animal Centre, Southern Medical University, Guangzhou, Guangdong, China
⨯
Hong-tao Li

* E-mail: gyhongtao@126.com

Affiliations First Affiliated Hospital, Guangzhou Medical University; Guangzhou, Guangdong, China, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China
⨯

Single Intraperitoneal Injection of Monocrotaline as a Novel Large Animal Model of Chronic Pulmonary Hypertension in Tibet Minipigs

Guang-qiao Zeng,
Rong Liu,
Hai-xing Liao,
Xin-feng Zhang,
Yuan-xin Qian,
Bao-hua Liu,
Qing-hong Wu,
Jin Zhao,
Wei-wang Gu,
Hong-tao Li

Published: November 11, 2013
https://doi.org/10.1371/journal.pone.0078965

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Pulmonary arteries
Is the Subject Area "Pulmonary arteries" applicable to this article?

Thanks for your feedback.
Echocardiography
Is the Subject Area "Echocardiography" applicable to this article?

Thanks for your feedback.
Blood pressure
Is the Subject Area "Blood pressure" applicable to this article?

Thanks for your feedback.
Pulmonary hypertension
Is the Subject Area "Pulmonary hypertension" applicable to this article?

Thanks for your feedback.
Systolic pressure
Is the Subject Area "Systolic pressure" applicable to this article?

Thanks for your feedback.
Cardiac ventricles
Is the Subject Area "Cardiac ventricles" applicable to this article?

Thanks for your feedback.
Pig models
Is the Subject Area "Pig models" applicable to this article?

Thanks for your feedback.
Heart
Is the Subject Area "Heart" applicable to this article?

Thanks for your feedback.