A Cell-Free Fluorometric High-Throughput Screen for Inhibitors of Rtt109-Catalyzed Histone Acetylation

Jayme L. Dahlin; Rondedrick Sinville; Jonathan Solberg; Hui Zhou; Junhong Han; Subhashree Francis; Jessica M. Strasser; Kristen John; Derek J. Hook; Michael A. Walters; Zhiguo Zhang

doi:10.1371/journal.pone.0078877

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Peer-reviewed

Research Article

A Cell-Free Fluorometric High-Throughput Screen for Inhibitors of Rtt109-Catalyzed Histone Acetylation

Jayme L. Dahlin,

Affiliations Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America, Medical Scientist Training Program, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Rondedrick Sinville,

Affiliation Institute for Therapeutics Discovery & Development, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Jonathan Solberg,

Affiliation Institute for Therapeutics Discovery & Development, University of Minnesota, Minneapolis, Minnesota, United States of America
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Hui Zhou,

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Junhong Han,

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Subhashree Francis,

Affiliation Institute for Therapeutics Discovery & Development, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Jessica M. Strasser,

Affiliation Institute for Therapeutics Discovery & Development, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Kristen John,

Affiliation Institute for Therapeutics Discovery & Development, University of Minnesota, Minneapolis, Minnesota, United States of America
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Derek J. Hook,

Affiliation Institute for Therapeutics Discovery & Development, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Michael A. Walters,

Affiliation Institute for Therapeutics Discovery & Development, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Zhiguo Zhang

* E-mail: zhang.zhiguo@mayo.edu

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯

A Cell-Free Fluorometric High-Throughput Screen for Inhibitors of Rtt109-Catalyzed Histone Acetylation

Jayme L. Dahlin,
Rondedrick Sinville,
Jonathan Solberg,
Hui Zhou,
Junhong Han,
Subhashree Francis,
Jessica M. Strasser,
Kristen John,
Derek J. Hook,
Michael A. Walters

Published: November 18, 2013
https://doi.org/10.1371/journal.pone.0078877

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