Protein Interaction Analysis of Senataxin and the ALS4 L389S Mutant Yields Insights into Senataxin Post-Translational Modification and Uncovers Mutant-Specific Binding with a Brain Cytoplasmic RNA-Encoded Peptide

• Craig L. Bennett ,

  * E-mail: crbennett@ucsd.edu

  Affiliations Comparative Genomics Centre, School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Queensland, Australia, Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America

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• Yingzhang Chen,

  Affiliation Department of Pediatrics, University of Washington Medical Center, Seattle, Washington, United States of America

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• Marissa Vignali,

  Affiliation Department of Genome Sciences, University of Washington Medical Center, Seattle, Washington, United States of America

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• Russell S. Lo,

  Affiliation Department of Genome Sciences, University of Washington Medical Center, Seattle, Washington, United States of America

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• Amanda G. Mason,

  Affiliation Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America

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• Asli Unal,

  Affiliation Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America

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• Nabiha P. Huq Saifee,

  Affiliation Department of Pharmacology, University of Washington Medical Center, Seattle, Washington, United States of America

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• Stanley Fields,

  Affiliation Department of Genome Sciences, University of Washington Medical Center, Seattle, Washington, United States of America

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• Albert R. La Spada

  Affiliations Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America, Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, California, United States of America, Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America, Rady Children’s Hospital, La Jolla, California, United States of America

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