The Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis Offers Efficient Bystander Cell Killing for Suicide Gene Therapy of Cancer

• Takeya Sato ,

  Contributed equally to this work with: Takeya Sato, Anton Neschadim

  * E-mail: tksato@med.tohoku.ac.jp

  Affiliation Molecular Pharmacology, Tohoku University, Sendai, Miyagi, Japan

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• Anton Neschadim ,

  Contributed equally to this work with: Takeya Sato, Anton Neschadim

  Affiliation Research & Development, Canadian Blood Services, Toronto, Ontario, Canada

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• Arnon Lavie,

  Affiliation Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America

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• Teruyuki Yanagisawa,

  Affiliation Molecular Pharmacology, Tohoku University, Sendai, Miyagi, Japan

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• Jeffrey A. Medin

  Affiliations Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, Institute of Medical Science, University of Toronto, Toronto, Canada, University Health Network, Toronto, Ontario, Canada

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