Red-Backed Vole Brain Promotes Highly Efficient In Vitro Amplification of Abnormal Prion Protein from Macaque and Human Brains Infected with Variant Creutzfeldt-Jakob Disease Agent

Julie Nemecek; Nabanita Nag; Christina M. Carlson; Jay R. Schneider; Dennis M. Heisey; Christopher J. Johnson; David M. Asher; Luisa Gregori

doi:10.1371/journal.pone.0078710

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Peer-reviewed

Research Article

Red-Backed Vole Brain Promotes Highly Efficient In Vitro Amplification of Abnormal Prion Protein from Macaque and Human Brains Infected with Variant Creutzfeldt-Jakob Disease Agent

Julie Nemecek,

Affiliation Laboratory of Bacterial and TSE Agents, Division of Emerging Transfusion-Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, United States of America
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Nabanita Nag,

Affiliation Laboratory of Bacterial and TSE Agents, Division of Emerging Transfusion-Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, United States of America
⨯
Christina M. Carlson,

Affiliations United States Geological Survey, National Wildlife Health Center, Madison, Wisconsin, United States of America, Program in Cellular and Molecular Biology, University of Wisconsin, Madison, Wisconsin, United States of America
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Jay R. Schneider,

Affiliation United States Geological Survey, National Wildlife Health Center, Madison, Wisconsin, United States of America
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Dennis M. Heisey,

Affiliation United States Geological Survey, National Wildlife Health Center, Madison, Wisconsin, United States of America
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Christopher J. Johnson,

Affiliation United States Geological Survey, National Wildlife Health Center, Madison, Wisconsin, United States of America
⨯
David M. Asher,

Affiliation Laboratory of Bacterial and TSE Agents, Division of Emerging Transfusion-Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, United States of America
⨯
Luisa Gregori

* E-mail: luisa.gregori@fda.hhs.gov

Affiliation Laboratory of Bacterial and TSE Agents, Division of Emerging Transfusion-Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, United States of America
⨯

Red-Backed Vole Brain Promotes Highly Efficient In Vitro Amplification of Abnormal Prion Protein from Macaque and Human Brains Infected with Variant Creutzfeldt-Jakob Disease Agent

Julie Nemecek,
Nabanita Nag,
Christina M. Carlson,
Jay R. Schneider,
Dennis M. Heisey,
Christopher J. Johnson,
David M. Asher,
Luisa Gregori

Published: October 24, 2013
https://doi.org/10.1371/journal.pone.0078710

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