A Phase 1b Randomized, Controlled, Double-Blinded Dosage-Escalation Trial to Evaluate the Safety, Reactogenicity and Immunogenicity of an Adenovirus Type 35 Based Circumsporozoite Malaria Vaccine in Burkinabe Healthy Adults 18 to 45 Years of Age

Alphonse Ouédraogo; Alfred B. Tiono; Désiré Kargougou; Jean Baptiste Yaro; Esperance Ouédraogo; Youssouf Kaboré; David Kangoye; Edith C. Bougouma; Adama Gansane; Noelie Henri; Amidou Diarra; Souleymane Sanon; Issiaka Soulama; Amadou T. Konate; Nora L. Watson; Valerie Brown; Jenny Hendriks; Maria Grazia Pau; Isabella Versteege; Edison Wiesken; Jerald Sadoff; Issa Nebie; Sodiomon B. Sirima

doi:10.1371/journal.pone.0078679

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Research Article

A Phase 1b Randomized, Controlled, Double-Blinded Dosage-Escalation Trial to Evaluate the Safety, Reactogenicity and Immunogenicity of an Adenovirus Type 35 Based Circumsporozoite Malaria Vaccine in Burkinabe Healthy Adults 18 to 45 Years of Age

Alphonse Ouédraogo,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Alfred B. Tiono,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Désiré Kargougou,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Jean Baptiste Yaro,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Esperance Ouédraogo,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Youssouf Kaboré,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
David Kangoye,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Edith C. Bougouma,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Adama Gansane,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Noelie Henri,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Amidou Diarra,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Souleymane Sanon,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Issiaka Soulama,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Amadou T. Konate,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
Nora L. Watson,

Affiliation EMMES Corporation, Rockville, Maryland, United States of America
⨯
Valerie Brown,

Affiliation EMMES Corporation, Rockville, Maryland, United States of America
⨯
Jenny Hendriks,

Affiliation Crucell Holland BV, Leiden, The Netherlands
⨯
Maria Grazia Pau,

Affiliation Crucell Holland BV, Leiden, The Netherlands
⨯
Isabella Versteege,

Affiliation Crucell Holland BV, Leiden, The Netherlands
⨯
Edison Wiesken,

Affiliation Crucell Holland BV, Leiden, The Netherlands
⨯
Jerald Sadoff,

Affiliation Crucell Holland BV, Leiden, The Netherlands
⨯
Issa Nebie,

Affiliation Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
⨯
[ ... ],
Sodiomon B. Sirima

* E-mail: s.sirima.cnlp@fasonet.bf

Affiliations Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso, Groupe d’action et de Recherche en Santé, Ouagadougou, Burkina Faso
⨯
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A Phase 1b Randomized, Controlled, Double-Blinded Dosage-Escalation Trial to Evaluate the Safety, Reactogenicity and Immunogenicity of an Adenovirus Type 35 Based Circumsporozoite Malaria Vaccine in Burkinabe Healthy Adults 18 to 45 Years of Age

Alphonse Ouédraogo,
Alfred B. Tiono,
Désiré Kargougou,
Jean Baptiste Yaro,
Esperance Ouédraogo,
Youssouf Kaboré,
David Kangoye,
Edith C. Bougouma,
Adama Gansane,
Noelie Henri

Published: November 11, 2013
https://doi.org/10.1371/journal.pone.0078679

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