Epstein-Barr Virus_Encoded LMP1 Upregulates MicroRNA-21 to Promote the Resistance of Nasopharyngeal Carcinoma Cells to Cisplatin-Induced Apoptosis by Suppressing PDCD4 and Fas-L

Guang-Da Yang; Tie-Jun Huang; Li-Xia Peng; Chang-Fu Yang; Ran-Yi Liu; Hong-Bing Huang; Qiao-Qiao Chu; Hong-Jie Yang; Jia-Ling Huang; Zhen-Yu Zhu; Chao-Nan Qian; Bi-Jun Huang

doi:10.1371/journal.pone.0078355

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Open Access

Peer-reviewed

Research Article

Epstein-Barr Virus_Encoded LMP1 Upregulates MicroRNA-21 to Promote the Resistance of Nasopharyngeal Carcinoma Cells to Cisplatin-Induced Apoptosis by Suppressing PDCD4 and Fas-L

Guang-Da Yang ,

Contributed equally to this work with: Guang-Da Yang, Tie-Jun Huang

Affiliation Department of Experimental Research, State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China
⨯
Tie-Jun Huang ,

Contributed equally to this work with: Guang-Da Yang, Tie-Jun Huang

Affiliation Department of Nuclear Medicine, the Second People’s Hospital of Shenzhen, Shenzhen, China
⨯
Li-Xia Peng,

Affiliation Department of Experimental Research, State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China
⨯
Chang-Fu Yang,

Affiliation Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
⨯
Ran-Yi Liu,

Affiliation Department of Experimental Research, State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China
⨯
Hong-Bing Huang,

Affiliation Department of Pharmacy, Cancer Center, Sun Yat-Sen University, Guangzhou, China
⨯
Qiao-Qiao Chu,

Affiliation School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
⨯
Hong-Jie Yang,

Affiliation Department of Experimental Research, State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China
⨯
Jia-Ling Huang,

Affiliation Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Zhen-Yu Zhu,

Affiliation Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
⨯
Chao-Nan Qian ,

* E-mail: qianchn@sysucc.org.cn (CNQ); huangbj@sysucc.org.cn (BJH)

Affiliation Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-Sen University, Guangzhou, China
⨯
Bi-Jun Huang

* E-mail: qianchn@sysucc.org.cn (CNQ); huangbj@sysucc.org.cn (BJH)

Affiliation Department of Experimental Research, State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, China
⨯

Epstein-Barr Virus_Encoded LMP1 Upregulates MicroRNA-21 to Promote the Resistance of Nasopharyngeal Carcinoma Cells to Cisplatin-Induced Apoptosis by Suppressing PDCD4 and Fas-L

Guang-Da Yang,
Tie-Jun Huang,
Li-Xia Peng,
Chang-Fu Yang,
Ran-Yi Liu,
Hong-Bing Huang,
Qiao-Qiao Chu,
Hong-Jie Yang,
Jia-Ling Huang,
Zhen-Yu Zhu

Published: October 23, 2013
https://doi.org/10.1371/journal.pone.0078355

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