Hyperuricemia Causes Pancreatic β-Cell Death and Dysfunction through NF-κB Signaling Pathway

Lu Jia; Jing Xing; Ying Ding; Yachen Shen; Xuhui Shi; Wei Ren; Meng Wan; Jianjin Guo; Shujing Zheng; Yun Liu; Xiubin Liang; Dongming Su

doi:10.1371/journal.pone.0078284

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Open Access

Peer-reviewed

Research Article

Hyperuricemia Causes Pancreatic β-Cell Death and Dysfunction through NF-κB Signaling Pathway

Lu Jia,

Affiliation Center of Metabolic Disease Research, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Jing Xing,

Affiliation Center of Metabolic Disease Research, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Ying Ding,

Affiliation Center of Metabolic Disease Research, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Yachen Shen,

Affiliation Center of Metabolic Disease Research, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Xuhui Shi,

Affiliation Center of Metabolic Disease Research, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Wei Ren,

Affiliation Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People’s Hospital; Shanghai Diabetes Institute; and Shanghai Clinical Center of Diabetes, Shanghai, China
⨯
Meng Wan,

Affiliation Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Jianjin Guo,

Affiliation Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People’s Hospital; Shanghai Diabetes Institute; and Shanghai Clinical Center of Diabetes, Shanghai, China
⨯
Shujing Zheng,

Affiliation Center of Metabolic Disease Research, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Yun Liu,

Affiliation Center of Metabolic Disease Research, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Xiubin Liang,

Affiliation Center of Metabolic Disease Research, Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯
Dongming Su

* E-mail: sudongming@njmu.edu.cn

Affiliations Center of Metabolic Disease Research, Nanjing Medical University, Nanjing, Jiangsu Province, China, Center of Cellular Therapy, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
⨯

Hyperuricemia Causes Pancreatic β-Cell Death and Dysfunction through NF-κB Signaling Pathway

Lu Jia,
Jing Xing,
Ying Ding,
Yachen Shen,
Xuhui Shi,
Wei Ren,
Meng Wan,
Jianjin Guo,
Shujing Zheng,
Yun Liu

Published: October 25, 2013
https://doi.org/10.1371/journal.pone.0078284

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