Antinociceptive Effects of Analgesic-Antitumor Peptide (AGAP), a Neurotoxin from the Scorpion Buthus martensii Karsch, on Formalin-Induced Inflammatory Pain through a Mitogen-Activated Protein Kinases–Dependent Mechanism in Mice

Qinghong Mao; Jiaping Ruan; Xueting Cai; Wuguang Lu; Juan Ye; Jie Yang; Yang Yang; Xiaoyan Sun; Junli Cao; Peng Cao

doi:10.1371/journal.pone.0078239

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Research Article

Antinociceptive Effects of Analgesic-Antitumor Peptide (AGAP), a Neurotoxin from the Scorpion Buthus martensii Karsch, on Formalin-Induced Inflammatory Pain through a Mitogen-Activated Protein Kinases–Dependent Mechanism in Mice

Qinghong Mao,

Affiliation Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, China
⨯
Jiaping Ruan ,

* E-mail: jpruan@163.com (JR); pcao79@yahoo.com (PC)

Affiliation Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, China
⨯
Xueting Cai,

Affiliations Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, China, Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Chinese Medicine, Nanjing, China
⨯
Wuguang Lu,

Affiliations Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, China, Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Chinese Medicine, Nanjing, China
⨯
Juan Ye,

Affiliations Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, China, Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Chinese Medicine, Nanjing, China
⨯
Jie Yang,

Affiliations Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, China, Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Chinese Medicine, Nanjing, China
⨯
Yang Yang,

Affiliations Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, China, Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Chinese Medicine, Nanjing, China
⨯
Xiaoyan Sun,

Affiliations Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, China, Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Chinese Medicine, Nanjing, China
⨯
Junli Cao,

Affiliation Jiangsu Key Laboratory of Anesthesiology, Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China
⨯
Peng Cao

* E-mail: jpruan@163.com (JR); pcao79@yahoo.com (PC)

Affiliations Jiangsu Branch of China Academy of Chinese Medical Sciences, Nanjing, China, Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Chinese Medicine, Nanjing, China
⨯

Antinociceptive Effects of Analgesic-Antitumor Peptide (AGAP), a Neurotoxin from the Scorpion Buthus martensii Karsch, on Formalin-Induced Inflammatory Pain through a Mitogen-Activated Protein Kinases–Dependent Mechanism in Mice

Qinghong Mao,
Jiaping Ruan,
Xueting Cai,
Wuguang Lu,
Juan Ye,
Jie Yang,
Yang Yang,
Xiaoyan Sun,
Junli Cao,
Peng Cao

Published: November 14, 2013
https://doi.org/10.1371/journal.pone.0078239

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