Administration of Heme Arginate Ameliorates Murine Type 2 Diabetes Independently of Heme Oxygenase Activity

Abhijeet K. Choudhary; Jillian Rennie; Carolynn Cairns; Gary Borthwick; Jeremy Hughes; Nicholas M. Morton; David Kluth; Bryan R. Conway

doi:10.1371/journal.pone.0078209

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Open Access

Peer-reviewed

Research Article

Administration of Heme Arginate Ameliorates Murine Type 2 Diabetes Independently of Heme Oxygenase Activity

Abhijeet K. Choudhary,

Affiliation Medical Research Council Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Jillian Rennie,

Affiliation University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Carolynn Cairns,

Affiliation University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Gary Borthwick,

Affiliation Medical Research Council Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Jeremy Hughes,

Affiliation Medical Research Council Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Nicholas M. Morton,

Affiliation University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
David Kluth,

Affiliation Medical Research Council Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯
Bryan R. Conway

* E-mail: bryan.conway@ed.ac.uk

Affiliations Medical Research Council Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom, University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
⨯

Administration of Heme Arginate Ameliorates Murine Type 2 Diabetes Independently of Heme Oxygenase Activity

Abhijeet K. Choudhary,
Jillian Rennie,
Carolynn Cairns,
Gary Borthwick,
Jeremy Hughes,
Nicholas M. Morton,
David Kluth,
Bryan R. Conway

Published: October 30, 2013
https://doi.org/10.1371/journal.pone.0078209

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Adipose tissue
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Adipocytes
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Type 2 diabetes
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