Complexes of Neutralizing and Non-Neutralizing Affinity Matured Fabs with a Mimetic of the Internal Trimeric Coiled-Coil of HIV-1 gp41

Elena Gustchina; Mi Li; Rodolfo Ghirlando; Peter Schuck; John M. Louis; Jason Pierson; Prashant Rao; Sriram Subramaniam; Alla Gustchina; G. Marius Clore; Alexander Wlodawer

doi:10.1371/journal.pone.0078187

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Peer-reviewed

Research Article

Complexes of Neutralizing and Non-Neutralizing Affinity Matured Fabs with a Mimetic of the Internal Trimeric Coiled-Coil of HIV-1 gp41

Elena Gustchina,

Affiliation Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Mi Li,

Affiliations Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland, United States of America, Basic Research Program, SAIC-Frederick, Frederick, Maryland, United States of America
⨯
Rodolfo Ghirlando,

Affiliation Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Peter Schuck,

Affiliation Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
John M. Louis,

Affiliation Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jason Pierson,

Affiliation FEI Company, Hillsboro, Oregon, United States of America
⨯
Prashant Rao,

Affiliation Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Sriram Subramaniam,

Affiliation Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Alla Gustchina ,

* E-mail: gustchia@mail.nih.gov (AG); mariusc@mail.nih.gov (GMC); wlodawer@nih.gov (AW)

Affiliation Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland, United States of America
⨯
G. Marius Clore ,

* E-mail: gustchia@mail.nih.gov (AG); mariusc@mail.nih.gov (GMC); wlodawer@nih.gov (AW)

Affiliation Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Alexander Wlodawer

* E-mail: gustchia@mail.nih.gov (AG); mariusc@mail.nih.gov (GMC); wlodawer@nih.gov (AW)

Affiliation Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland, United States of America
⨯

Complexes of Neutralizing and Non-Neutralizing Affinity Matured Fabs with a Mimetic of the Internal Trimeric Coiled-Coil of HIV-1 gp41

Elena Gustchina,
Mi Li,
Rodolfo Ghirlando,
Peter Schuck,
John M. Louis,
Jason Pierson,
Prashant Rao,
Sriram Subramaniam,
Alla Gustchina,
G. Marius Clore

Published: November 7, 2013
https://doi.org/10.1371/journal.pone.0078187

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