Whole Exome Sequencing Identifies a Troponin T Mutation Hot Spot in Familial Dilated Cardiomyopathy

Nzali Campbell; Gianfranco Sinagra; Kenneth L. Jones; Dobromir Slavov; Katherine Gowan; Marco Merlo; Elisa Carniel; Pamela R. Fain; Pierluigi Aragona; Andrea Di Lenarda; Luisa Mestroni; Matthew R. G. Taylor

doi:10.1371/journal.pone.0078104

Loading metrics

Open Access

Peer-reviewed

Research Article

Whole Exome Sequencing Identifies a Troponin T Mutation Hot Spot in Familial Dilated Cardiomyopathy

Nzali Campbell,

Affiliation Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, Colorado, United States of America
⨯
Gianfranco Sinagra,

Affiliation Cardiovascular Department, “Ospedali Riuniti” and University of Trieste, Trieste, Italy
⨯
Kenneth L. Jones,

Affiliation Bioinformatics Shared Resource of the University of Colorado Cancer Center and the Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
Dobromir Slavov,

Affiliation Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, Colorado, United States of America
⨯
Katherine Gowan,

Affiliation Bioinformatics Shared Resource of the University of Colorado Cancer Center and the Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
Marco Merlo,

Affiliation Cardiovascular Department, “Ospedali Riuniti” and University of Trieste, Trieste, Italy
⨯
Elisa Carniel,

Affiliation Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, Colorado, United States of America
⨯
Pamela R. Fain,

Affiliation Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, Colorado, United States of America
⨯
Pierluigi Aragona,

Affiliation Cardiology Unit, Ospedale Trebisacce, Cosenza, Italy
⨯
Andrea Di Lenarda,

Affiliation Cardiovascular Department, “Ospedali Riuniti” and University of Trieste, Trieste, Italy
⨯
Luisa Mestroni ,

* E-mail: matthew.taylor@ucdenver.edu (MRGT); Luisa.Mestroni@ucdenver.edu (LM)

Affiliation Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, Colorado, United States of America
⨯
Matthew R. G. Taylor

* E-mail: matthew.taylor@ucdenver.edu (MRGT); Luisa.Mestroni@ucdenver.edu (LM)

Affiliation Cardiovascular Institute and Adult Medical Genetics, University of Colorado, Aurora, Colorado, United States of America
⨯

Whole Exome Sequencing Identifies a Troponin T Mutation Hot Spot in Familial Dilated Cardiomyopathy

Nzali Campbell,
Gianfranco Sinagra,
Kenneth L. Jones,
Dobromir Slavov,
Katherine Gowan,
Marco Merlo,
Elisa Carniel,
Pamela R. Fain,
Pierluigi Aragona,
Andrea Di Lenarda

Published: October 29, 2013
https://doi.org/10.1371/journal.pone.0078104

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Haplotypes
Is the Subject Area "Haplotypes" applicable to this article?

Thanks for your feedback.
Bioinformatics
Is the Subject Area "Bioinformatics" applicable to this article?

Thanks for your feedback.
Cardiomyopathies
Is the Subject Area "Cardiomyopathies" applicable to this article?

Thanks for your feedback.
Dideoxy DNA sequencing
Is the Subject Area "Dideoxy DNA sequencing" applicable to this article?

Thanks for your feedback.
Gene sequencing
Is the Subject Area "Gene sequencing" applicable to this article?

Thanks for your feedback.
Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.
Polyvinyl chloride
Is the Subject Area "Polyvinyl chloride" applicable to this article?

Thanks for your feedback.
Single nucleotide polymorphisms
Is the Subject Area "Single nucleotide polymorphisms" applicable to this article?

Thanks for your feedback.