Slow Proton Transfer Coupled to Unfolding Explains the Puzzling Results of Single-Molecule Experiments on BBL, a Paradigmatic Downhill Folding Protein

Open Access

Peer-reviewed

Research Article

Michele Cerminara,

Affiliations Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain, IMDEA-Nanociencia, Madrid, Spain
⨯
Luis A. Campos,

Affiliations Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain, IMDEA-Nanociencia, Madrid, Spain
⨯
Ravishankar Ramanathan,

Affiliation Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain
⨯
Victor Muñoz

* E-mail: vmunoz@cnb.csic.es

Affiliations Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain, IMDEA-Nanociencia, Madrid, Spain, Department of Chemistry and Biochemistry, University of Maryland. College Park, Maryland, United States of America
⨯

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Denaturation
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Protein folding
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Protons
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Free energy
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Thermodynamics
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Fluorescence resonance energy transfer
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Protein denaturation
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Lasers
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