Rational Design, Synthesis, and Biological Evaluation of Third Generation α-Noscapine Analogues as Potent Tubulin Binding Anti-Cancer Agents

Naresh Kumar Manchukonda; Pradeep Kumar Naik; Seneha Santoshi; Manu Lopus; Silja Joseph; Balasubramanian Sridhar; Srinivas Kantevari

doi:10.1371/journal.pone.0077970

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Open Access

Peer-reviewed

Research Article

Rational Design, Synthesis, and Biological Evaluation of Third Generation α-Noscapine Analogues as Potent Tubulin Binding Anti-Cancer Agents

Naresh Kumar Manchukonda,

Affiliation Organic Chemistry Division-II (Crop Protection Chemicals Division), CSIR-Indian Institute of Chemical Technology, Hyderabad, India
⨯
Pradeep Kumar Naik ,

* E-mail: pknaik1973@gmail.com (PKN); kantevari@yahoo.com (SK)

Affiliation Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Distt, Solan, Himachal Pradesh, India
⨯
Seneha Santoshi,

Affiliation Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Distt, Solan, Himachal Pradesh, India
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Manu Lopus,

Affiliations Department of Molecular, Cellular, and Developmental Biology, and the Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, United States of America, UM-DAE Centre for Excellence in Basic Sciences, University of Mumbai campus, Kalina, Santa Cruz (E), Mumbai, India
⨯
Silja Joseph,

Affiliation Department of Molecular, Cellular, and Developmental Biology, and the Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California, United States of America
⨯
Balasubramanian Sridhar,

Affiliation X-Ray Crystallography Laboratory, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India
⨯
Srinivas Kantevari

* E-mail: pknaik1973@gmail.com (PKN); kantevari@yahoo.com (SK)

Affiliations Organic Chemistry Division-II (Crop Protection Chemicals Division), CSIR-Indian Institute of Chemical Technology, Hyderabad, India, Academy of Scientific and Innovative Research, CSIR-Indian Institute of Chemical Technology, Hyderabad, India
⨯

Rational Design, Synthesis, and Biological Evaluation of Third Generation α-Noscapine Analogues as Potent Tubulin Binding Anti-Cancer Agents

Naresh Kumar Manchukonda,
Pradeep Kumar Naik,
Seneha Santoshi,
Manu Lopus,
Silja Joseph,
Balasubramanian Sridhar,
Srinivas Kantevari

Published: October 21, 2013
https://doi.org/10.1371/journal.pone.0077970

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