Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats

Xiang-Shan Tan; Jing-Yi Ma; Ru Feng; Chao Ma; Wen-Jing Chen; Yu-Peng Sun; Jie Fu; Min Huang; Chi-Yu He; Jia-Wen Shou; Wen-Yi He; Yan Wang; Jian-Dong Jiang

doi:10.1371/journal.pone.0077969

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Open Access

Peer-reviewed

Research Article

Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats

Xiang-Shan Tan ,

Contributed equally to this work with: Xiang-Shan Tan, Jing-Yi Ma, Ru Feng

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Jing-Yi Ma ,

Contributed equally to this work with: Xiang-Shan Tan, Jing-Yi Ma, Ru Feng

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Ru Feng ,

Contributed equally to this work with: Xiang-Shan Tan, Jing-Yi Ma, Ru Feng

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Chao Ma,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Wen-Jing Chen,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Yu-Peng Sun,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Jie Fu,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Min Huang,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Chi-Yu He,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Jia-Wen Shou,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Wen-Yi He,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Yan Wang ,

* E-mail: wangyan@imm.ac.cn (YW); jiang.jdong@163.com (JDJ)

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Jian-Dong Jiang

* E-mail: wangyan@imm.ac.cn (YW); jiang.jdong@163.com (JDJ)

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯

Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats

Xiang-Shan Tan,
Jing-Yi Ma,
Ru Feng,
Chao Ma,
Wen-Jing Chen,
Yu-Peng Sun,
Jie Fu,
Min Huang,
Chi-Yu He,
Jia-Wen Shou

Published: October 31, 2013
https://doi.org/10.1371/journal.pone.0077969

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