Folate Deficiency Triggers an Oxidative-Nitrosative Stress-Mediated Apoptotic Cell Death and Impedes Insulin Biosynthesis in RINm5F Pancreatic Islet β–Cells: Relevant to the Pathogenesis of Diabetes

• Hung-Chih Hsu ,

  Contributed equally to this work with: Hung-Chih Hsu, Jeng-Fong Chiou

  Affiliations Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Department of Physical Medicine and Rehabilitation, Chia-Yi Chang Gung Memorial Hospital, Chia-Yi, Taiwan, Department of Nursing, Chang-Gung University of Science and Technology, Chia-Yi, Taiwan

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• Jeng-Fong Chiou ,

  Contributed equally to this work with: Hung-Chih Hsu, Jeng-Fong Chiou

  Affiliation Cancer Center and Department of Radiation Oncology, Taipei Medical University and Hospital, Taipei, Taiwan

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• Yu-Huei Wang,

  Affiliation Translational Research Laboratory, Cancer Center, Taipei Medical University and Hospital, Taipei, Taiwan

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• Chia-Hui Chen,

  Affiliation Translational Research Laboratory, Cancer Center, Taipei Medical University and Hospital, Taipei, Taiwan

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• Shin-Yi Mau,

  Affiliation Translational Research Laboratory, Cancer Center, Taipei Medical University and Hospital, Taipei, Taiwan

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• Chun-Te Ho,

  Affiliation Translational Research Laboratory, Cancer Center, Taipei Medical University and Hospital, Taipei, Taiwan

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• Pey-Jium Chang,

  Affiliation Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan

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• Tsan-Zon Liu ,

  * E-mail: tzliu@tmuh.org.tw (TZL); chench@mail.ncyu.edu.tw (CHC)

  Affiliation Translational Research Laboratory, Cancer Center, Taipei Medical University and Hospital, Taipei, Taiwan

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• Ching-Hsein Chen

  * E-mail: tzliu@tmuh.org.tw (TZL); chench@mail.ncyu.edu.tw (CHC)

  Affiliation Department of Microbiology, Immunology and Biopharmaceuticals, Collage of Life Sciences, National Chiayi University, Chiayi City, Taiwan

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