PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads

Edward Seung; Timothy E. Dudek; Todd M. Allen; Gordon J. Freeman; Andrew D. Luster; Andrew M. Tager

doi:10.1371/journal.pone.0077780

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Peer-reviewed

Research Article

PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads

Edward Seung ,

* E-mail: seung.edward@mgh.harvard.edu (ES); amtager@partners.org (AMT)

Affiliations Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Timothy E. Dudek,

Affiliation Ragon Institute of MGH, Massachusetts Institutes of Technology, and Harvard, Cambridge, Massachusetts, United States of America
⨯
Todd M. Allen,

Affiliation Ragon Institute of MGH, Massachusetts Institutes of Technology, and Harvard, Cambridge, Massachusetts, United States of America
⨯
Gordon J. Freeman,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Andrew D. Luster,

Affiliations Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯
Andrew M. Tager

* E-mail: seung.edward@mgh.harvard.edu (ES); amtager@partners.org (AMT)

Affiliations Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America, Pulmonary and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯

PD-1 Blockade in Chronically HIV-1-Infected Humanized Mice Suppresses Viral Loads

Edward Seung,
Timothy E. Dudek,
Todd M. Allen,
Gordon J. Freeman,
Andrew D. Luster,
Andrew M. Tager

Published: October 21, 2013
https://doi.org/10.1371/journal.pone.0077780

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