PD-0332991, a CDK4/6 Inhibitor, Significantly Prolongs Survival in a Genetically Engineered Mouse Model of Brainstem Glioma

Kelly L. Barton; Katherine Misuraca; Francisco Cordero; Elena Dobrikova; Hooney D. Min; Matthias Gromeier; David G. Kirsch; Oren J. Becher

doi:10.1371/journal.pone.0077639

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Peer-reviewed

Research Article

PD-0332991, a CDK4/6 Inhibitor, Significantly Prolongs Survival in a Genetically Engineered Mouse Model of Brainstem Glioma

Kelly L. Barton,

Affiliations Department of Pediatrics, Duke University, Durham, North Carolina, United States of America, Preston Robert Tisch Brain Tumor Center, Duke University, Durham, North Carolina, United States of America
⨯
Katherine Misuraca,

Affiliation Graduate Program in Molecular Cancer Biology, Duke University, Durham, North Carolina, United States of America
⨯
Francisco Cordero,

Affiliations Department of Pediatrics, Duke University, Durham, North Carolina, United States of America, Department of Pathology, Duke University, Durham, North Carolina, United States of America, Preston Robert Tisch Brain Tumor Center, Duke University, Durham, North Carolina, United States of America
⨯
Elena Dobrikova,

Affiliation Department of Surgery, Duke University, Durham, North Carolina, United States of America
⨯
Hooney D. Min,

Affiliation Department of Radiation Oncology, Duke University, Durham, North Carolina, United States of America
⨯
Matthias Gromeier,

Affiliation Department of Surgery, Duke University, Durham, North Carolina, United States of America
⨯
David G. Kirsch,

Affiliations Department of Radiation Oncology, Duke University, Durham, North Carolina, United States of America, Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina, United States of America
⨯
Oren J. Becher

* E-mail: oren.becher@duke.edu

Affiliations Department of Pediatrics, Duke University, Durham, North Carolina, United States of America, Department of Pathology, Duke University, Durham, North Carolina, United States of America, Preston Robert Tisch Brain Tumor Center, Duke University, Durham, North Carolina, United States of America
⨯

PD-0332991, a CDK4/6 Inhibitor, Significantly Prolongs Survival in a Genetically Engineered Mouse Model of Brainstem Glioma

Kelly L. Barton,
Katherine Misuraca,
Francisco Cordero,
Elena Dobrikova,
Hooney D. Min,
Matthias Gromeier,
David G. Kirsch,
Oren J. Becher

Published: October 2, 2013
https://doi.org/10.1371/journal.pone.0077639

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