In-Vivo Efficacy of Compliant 3D Nano-Composite in Critical-Size Bone Defect Repair: a Six Month Preclinical Study in Rabbit

Nitin Sagar; Alok K. Pandey; Deepak Gurbani; Kainat Khan; Dhirendra Singh; Bhushan P. Chaudhari; Vivek P. Soni; Naibedya Chattopadhyay; Alok Dhawan; Jayesh R. Bellare

doi:10.1371/journal.pone.0077578

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Open Access

Peer-reviewed

Research Article

In-Vivo Efficacy of Compliant 3D Nano-Composite in Critical-Size Bone Defect Repair: a Six Month Preclinical Study in Rabbit

Nitin Sagar,

Affiliation Department of Biosciences and Bioengineering, Indian Institute of Technology-Bombay, Mumbai, Maharashtra, India
⨯
Alok K. Pandey,

Affiliation Nanomaterial Toxicology Group, Council for Scientific and Industrial Research-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India
⨯
Deepak Gurbani,

Affiliation Nanomaterial Toxicology Group, Council for Scientific and Industrial Research-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India
⨯
Kainat Khan,

Affiliation Division of Endocrinology, Central Drug Research Institute (Council of Scientific and 12 Industrial Research), Lucknow, Uttar Pradesh, India
⨯
Dhirendra Singh,

Affiliation Regulatory toxicology group, Council for Scientific and Industrial Research-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India
⨯
Bhushan P. Chaudhari,

Affiliation Regulatory toxicology group, Council for Scientific and Industrial Research-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India
⨯
Vivek P. Soni,

Affiliation Department of Biosciences and Bioengineering, Indian Institute of Technology-Bombay, Mumbai, Maharashtra, India
⨯
Naibedya Chattopadhyay,

Affiliation Division of Endocrinology, Central Drug Research Institute (Council of Scientific and 12 Industrial Research), Lucknow, Uttar Pradesh, India
⨯
Alok Dhawan,

Affiliations Nanomaterial Toxicology Group, Council for Scientific and Industrial Research-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, India, Institute of Life Sciences, Ahmedabad University, Ahmedabad, Gujarat, India
⨯
Jayesh R. Bellare

* E-mail: jb@iitb.ac.in

Affiliations Department of Biosciences and Bioengineering, Indian Institute of Technology-Bombay, Mumbai, Maharashtra, India, Department of Chemical Engineering, Indian Institute of Technology-Bombay, Mumbai, Maharashtra, India
⨯

In-Vivo Efficacy of Compliant 3D Nano-Composite in Critical-Size Bone Defect Repair: a Six Month Preclinical Study in Rabbit

Nitin Sagar,
Alok K. Pandey,
Deepak Gurbani,
Kainat Khan,
Dhirendra Singh,
Bhushan P. Chaudhari,
Vivek P. Soni,
Naibedya Chattopadhyay,
Alok Dhawan,
Jayesh R. Bellare

Published: October 18, 2013
https://doi.org/10.1371/journal.pone.0077578

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Bone fracture
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Tissue repair
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Rabbits
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Surgical and invasive medical procedures
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Bone development
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Histology
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Bone remodeling
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Medical implants
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