Synthetic Oxoisoaporphine Alkaloids: In Vitro, In Vivo and In Silico Assessment of Antileishmanial Activities

Eduardo Sobarzo-Sánchez; Pablo Bilbao-Ramos; Maria Dea-Ayuela; Humberto González-Díaz; Matilde Yañez; Eugenio Uriarte; Lourdes Santana; Victoria Martínez-Sernández; Francisco Bolás-Fernández; Florencio M. Ubeira

doi:10.1371/journal.pone.0077560

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Peer-reviewed

Research Article

Synthetic Oxoisoaporphine Alkaloids: In Vitro, In Vivo and In Silico Assessment of Antileishmanial Activities

Eduardo Sobarzo-Sánchez,

Affiliations Departamento de Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago, Chile
⨯
Pablo Bilbao-Ramos,

Affiliation Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
⨯
Maria Dea-Ayuela,

Affiliation Departamento de Farmacia, Universidad Cardenal Herrera, Valencia, Spain
⨯
Humberto González-Díaz,

Current address: Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco UPV/EHU, Bizkaia, País Vasco, Spain; IKERBASQUE, Fundación Vasca para la Ciencia, Bilbao, Spain

Affiliation Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
⨯
Matilde Yañez,

Affiliation Departamento de Farmacología, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
⨯
Eugenio Uriarte,

Affiliation Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
⨯
Lourdes Santana,

Affiliation Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
⨯
Victoria Martínez-Sernández,

Affiliation Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
⨯
Francisco Bolás-Fernández,

Affiliation Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
⨯
Florencio M. Ubeira

* E-mail: fm.ubeira@usc.es

Affiliation Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
⨯

Synthetic Oxoisoaporphine Alkaloids: In Vitro, In Vivo and In Silico Assessment of Antileishmanial Activities

Eduardo Sobarzo-Sánchez,
Pablo Bilbao-Ramos,
Maria Dea-Ayuela,
Humberto González-Díaz,
Matilde Yañez,
Eugenio Uriarte,
Lourdes Santana,
Victoria Martínez-Sernández,
Francisco Bolás-Fernández,
Florencio M. Ubeira

Published: October 29, 2013
https://doi.org/10.1371/journal.pone.0077560

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