Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes

Aileen J. F. King; Yongjing Guo; Dongsheng Cai; Jennifer Hollister-Lock; Brooke Morris; Alison Salvatori; John A. Corbett; Susan Bonner-Weir; Steven E. Shoelson; Gordon C. Weir

doi:10.1371/journal.pone.0077452

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Open Access

Peer-reviewed

Research Article

Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes

Aileen J. F. King,

Affiliations Diabetes Research Group, King's College London, London, United Kingdom, Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Yongjing Guo,

Affiliation Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Dongsheng Cai,

Affiliation Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jennifer Hollister-Lock,

Affiliation Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Brooke Morris,

Affiliation Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Alison Salvatori,

Affiliation Department of Pharmacology & Physiology, Saint Louis University, St. Louis, Missouri, United States of America
⨯
John A. Corbett,

Affiliation Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Susan Bonner-Weir,

Affiliation Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Steven E. Shoelson,

Affiliation Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Gordon C. Weir

* E-mail: gordon.weir@joslin.harvard.edu

Affiliation Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes

Aileen J. F. King,
Yongjing Guo,
Dongsheng Cai,
Jennifer Hollister-Lock,
Brooke Morris,
Alison Salvatori,
John A. Corbett,
Susan Bonner-Weir,
Steven E. Shoelson,
Gordon C. Weir

Published: October 18, 2013
https://doi.org/10.1371/journal.pone.0077452

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